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KMID : 0853020080110020079
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Journal of Korean Burn Society
2008 Volume.11 No. 2 p.79 ~ p.84
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Recombinant Human Epidermal Growth Factor
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Woo Go-Woon
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Abstract
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Wound healing has three physiological steps; inflammation, proliferation and remodeling. It is a very complicated and systematic process involving inflammation, synthesis and maturation of collagen, fibroblast activity, neovascularization and factor epithelial migration, and there are many unknown informations. The growth factors such as Epidermal growth factor (EGF), platelet-derived growth factor (PDGF), fibroblast growth factor, keratinocyte growth factor, transforming growth factor-b, vascular endothelial growth factor and granulocyte colony-stimulating take an important role in this process. Epidermal growth factor (EGF) derived from platelets, macrophages and monocytes stimulates epithelial cells, fibroblasts and smooth muscle cells to make a wound healing. EGF had found out in submandibular gland of mouse in 1962, by Cohen and many studies have investigated the role of EGF as a strong mitogen related to receptors of epidermal cells and fibroblasts to make an epithelialization and as a chemoattractant to make a neovascularization. EGF also helps a wound healing in a chronic radiation ulcer, diabetic foot ulcer and Op wound like a gstrojejunostomy. Therefore, now it is time to make results from the role of EGF in burn.
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KEYWORD
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Wound healing, Epidermal growth factor, Epithelialization
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